Factor VII Antikörper
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- Target Alle Factor VII (F7) Antikörper anzeigen
- Factor VII (F7) (Coagulation Factor VII (F7))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Factor VII Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- Upon activation of the factor VII, proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts Factor VII (FVII) to an activated two-chain form (FVIIa). A heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated. Since the immunogen sequence locates within the heavy chain, it should recognize both Factor VII and Factor VIIa.
- Kreuzreaktivität
- Human, Maus
- Produktmerkmale
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Rabbit polyclonal antibody to Factor VII (coagulation factor VII (serum prothrombin conversion accelerator))
Factor VII antibody [N3C3] - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human Factor VII. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product F7 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: NIH-3T3
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 2.32 mg/mL
- Buffer
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- Factor VII (F7) (Coagulation Factor VII (F7))
- Andere Bezeichnung
- coagulation factor VII (F7 Produkte)
- Synonyme
- F7 antikoerper, wu:fb59f04 antikoerper, zgc:109870 antikoerper, SPCA antikoerper, AI114908 antikoerper, ATIII antikoerper, At-3 antikoerper, At3 antikoerper, LOC100223776 antikoerper, AI132620 antikoerper, Cf7 antikoerper, FVII antikoerper, mfVII antikoerper, f7 antikoerper, coagulation factor VII antikoerper, serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 antikoerper, coagulation factor 7 (serum prothrombin conversion accelerator) S homeolog antikoerper, F7 antikoerper, f7 antikoerper, Serpinc1 antikoerper, CpipJ_CPIJ009142 antikoerper, CpipJ_CPIJ010295 antikoerper, CpipJ_CPIJ020127 antikoerper, fa7 antikoerper, f7.S antikoerper
- Hintergrund
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This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.
Cellular Localization: Secreted - Molekulargewicht
- 52 kDa
- Gen-ID
- 2155
- UniProt
- P08709
- Pathways
- Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling
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