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Factor VII Antikörper

F7 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2854983
  • Target Alle Factor VII (F7) Antikörper anzeigen
    Factor VII (F7) (Coagulation Factor VII (F7))
    Reaktivität
    • 53
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 47
    • 10
    • 9
    • 1
    • 1
    Kaninchen
    Klonalität
    • 59
    • 9
    Polyklonal
    Konjugat
    • 43
    • 15
    • 4
    • 3
    • 1
    • 1
    • 1
    Dieser Factor VII Antikörper ist unkonjugiert
    Applikation
    • 52
    • 25
    • 24
    • 11
    • 9
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Upon activation of the factor VII, proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts Factor VII (FVII) to an activated two-chain form (FVIIa). A heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated. Since the immunogen sequence locates within the heavy chain, it should recognize both Factor VII and Factor VIIa.
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Rabbit polyclonal antibody to Factor VII (coagulation factor VII (serum prothrombin conversion accelerator))
    Factor VII antibody [N3C3]
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human Factor VII. The exact sequence is proprietary.
    Isotyp
    IgG
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  • Applikationshinweise
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: NIH-3T3

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2.32 mg/mL
    Buffer
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    Factor VII (F7) (Coagulation Factor VII (F7))
    Andere Bezeichnung
    coagulation factor VII (F7 Produkte)
    Synonyme
    F7 antikoerper, wu:fb59f04 antikoerper, zgc:109870 antikoerper, SPCA antikoerper, AI114908 antikoerper, ATIII antikoerper, At-3 antikoerper, At3 antikoerper, LOC100223776 antikoerper, AI132620 antikoerper, Cf7 antikoerper, FVII antikoerper, mfVII antikoerper, f7 antikoerper, coagulation factor VII antikoerper, serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 antikoerper, coagulation factor 7 (serum prothrombin conversion accelerator) S homeolog antikoerper, F7 antikoerper, f7 antikoerper, Serpinc1 antikoerper, CpipJ_CPIJ009142 antikoerper, CpipJ_CPIJ010295 antikoerper, CpipJ_CPIJ020127 antikoerper, fa7 antikoerper, f7.S antikoerper
    Hintergrund
    This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy.

    Cellular Localization: Secreted
    Molekulargewicht
    52 kDa
    Gen-ID
    2155
    UniProt
    P08709
    Pathways
    Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling
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