ATRX Antikörper (C-Term)

Produktnummer ABIN2855005

Produktdetails anti-ATRX Antikörper

Target: ATRX (helicase 2, X-linked (ATRX))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATRX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Kreuzreaktivität: Schimpanse

Kreuzreaktivität (Details): Chimpanzee (100 %)

Produktmerkmale: Rabbit Polyclonal antibody to ATRX (alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae))
ATRX antibody [C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*

Kommentare:

Positive Control: 293T , A431 , HeLa , HepG2 , NIH3T3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2.67 mg/mL

Buffer: 1XPBS, 20 % Glycerol ( pH 7). 0.025 % ProClin 300 was added as a preservative.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX (ATRX Produkte)

Synonyme: ATR2 antikoerper, JMS antikoerper, MRXHF1 antikoerper, RAD54 antikoerper, RAD54L antikoerper, SFM1 antikoerper, SHS antikoerper, XH2 antikoerper, XNP antikoerper, ZNF-HX antikoerper, 4833408C14Rik antikoerper, AI447451 antikoerper, DXHXS6677E antikoerper, HP1-BP38 antikoerper, Hp1bp2 antikoerper, Hp1bp38 antikoerper, MRXS3 antikoerper, Rad54 antikoerper, Xnp antikoerper, atrx antikoerper, rad54 antikoerper, atrxl antikoerper, wu:fb26e12 antikoerper, wu:fb52h08 antikoerper, wu:fb72g09 antikoerper, wu:fb94e07 antikoerper, zgc:66223 antikoerper, ATRX, chromatin remodeler antikoerper, alpha thalassemia/mental retardation syndrome X-linked L homeolog antikoerper, alpha thalassemia/mental retardation syndrome X-linked homolog (human) antikoerper, ATRX antikoerper, Atrx antikoerper, atrx.L antikoerper, atrx antikoerper

Hintergrund: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Molekulargewicht: 283 kDa

Gen-ID: 546