Lactate Dehydrogenase A Antikörper

Produktnummer ABIN2855034

Produktdetails anti-Lactate Dehydrogenase A Antikörper

Target: Lactate Dehydrogenase A (LDHA)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lactate Dehydrogenase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to Lactate Dehydrogenase (lactate dehydrogenase A)
LDHA antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human LDHA. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: PC-12 , Rat2 , Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , 293T , A431 , HeLa , HepG2

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.33 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-Lactate Dehydrogenase A Antikörper (ABIN2855034)

Thompson, Alvarez, Singha, Pavesic, Nguyen, Nelson, Fruman, Razorenova: "Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism." in: Molecular cancer therapeutics, Vol. 17, Issue 8, pp. 1781-1792, (2019) (PubMed).

Zera, Zastre: "Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes." in: PLoS ONE, Vol. 12, Issue 10, pp. e0186707, (2017) (PubMed).

Ugun-Klusek, Tatham, Elkharaz, Constantin-Teodosiu, Lawler, Mohamed, Paine, Anderson, John Mayer, Lowe, Ellen Billett, Bedford: "Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway." in: Cell death & disease, Vol. 8, Issue 1, pp. e2531, (2017) (PubMed).

Details zu Lactate Dehydrogenase A

Target: Lactate Dehydrogenase A (LDHA)

Andere Bezeichnung: lactate dehydrogenase A (LDHA Produkte)

Synonyme: GSD11 antikoerper, LDH1 antikoerper, LDHM antikoerper, LDH-M antikoerper, ldh-h antikoerper, ldha antikoerper, ldha-B antikoerper, ldhbb antikoerper, trg-5 antikoerper, Ldh1 antikoerper, Ldhm antikoerper, l7R2 antikoerper, gsd11 antikoerper, ldh-m antikoerper, ldh1 antikoerper, ldhm antikoerper, pig19 antikoerper, ldha1 antikoerper, ldhab antikoerper, LDH-A antikoerper, LDHC antikoerper, lactate dehydrogenase A antikoerper, lactate dehydrogenase B L homeolog antikoerper, lactate dehydrogenase A4 antikoerper, lactate dehydrogenase A L homeolog antikoerper, L-lactate dehydrogenase A chain antikoerper, LDHA antikoerper, ldhb.L antikoerper, Ldha antikoerper, ldha antikoerper, ldha.L antikoerper, LOC100713875 antikoerper

Hintergrund: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Cellular Localization: Cytoplasm

Molekulargewicht: 37 kDa

Gen-ID: 3939

UniProt: P00338

Pathways: Warburg Effekt