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APOE Antikörper (N-Term)

Name: APOE Antikörper (N-Term)
Brand: antibodies-online
SKU: ABIN2855049
Price: 630.63 EUR
Availability: InStock

APOE Reaktivität: Human WB, IHC (p), ICC, IF Wirt: Kaninchen Polyclonal unconjugated

WB Image Whole cell extract (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Apolipoprotein E antibody , diluted at 1:1000. (APOE Antikörper (N-Term))

IHC-P Image Apolipoprotein E antibody detects Apolipoprotein E protein at secreted on human hepatoma by immunohistochemical analysis. (APOE Antikörper (N-Term))

IHC

WB Image Human tissue extract (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Apolipoprotein E antibody , diluted at 1:1000. (APOE Antikörper (N-Term))

3 Abbildungen

(1 reference)

Produktnummer ABIN2855049

Datenblatt (PDF)

Target Alle APOE Antikörper anzeigen

APOE (Apolipoprotein E (APOE))
Bindungsspezifität
15

15

15

5

5

5

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
Reaktivität
105

75

56

2

2

2

1

1

1
Human
Wirt
105

23

14

2
Kaninchen
Passende Sekundärantikörper
Klonalität
109

34
Polyklonal
Konjugat
59

17

11

7

3

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2
Dieser APOE Antikörper ist unkonjugiert
Applikation
107

57

39

39

31

24

19

12

8

7

6

5

4

2

2

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)

Kreuzreaktivität

Human

Produktmerkmale

Rabbit Polyclonal antibody to Apolipoprotein E (apolipoprotein E)
Apolipoprotein E antibody

Aufreinigung

Purified by antigen-affinity chromatography.

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human Apolipoprotein E. The exact sequence is proprietary.

Isotyp

IgG

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Applikationshinweise

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare

Positive Control: A549 , human plasma

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel

Thimerosal (Merthiolate)

Vorsichtsmaßnahmen

This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Ellis, Naugler, Nauglers, Parini, Mörk, Jorns, Zemack, Sandblom, Björkhem, Ericzon, Wilson, Strom, Grompe: "Mice with chimeric livers are an improved model for human lipoprotein metabolism." in: PLoS ONE, Vol. 8, Issue 11, pp. e78550, (2014) (PubMed).
Target

APOE (Apolipoprotein E (APOE))

Andere Bezeichnung

apolipoprotein E (APOE Produkte)

Synonyme

ad2 antikoerper, apoprotein antikoerper, im:7036787 antikoerper, wu:fb69a05 antikoerper, zgc:110064 antikoerper, apoe antikoerper, AI255918 antikoerper, AD2 antikoerper, LDLCQ5 antikoerper, LPG antikoerper, APOEA antikoerper, Apo-E antikoerper, apolipoprotein E antikoerper, apolipoprotein Ea antikoerper, apoe antikoerper, apoea antikoerper, Apoe antikoerper, APOE antikoerper

Hintergrund

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Cellular Localization: Secreted

Molekulargewicht

36 kDa

Gen-ID

348

UniProt

P02649

Pathways

Regulation of Cell Size, Lipid Metabolism