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NLRC4 Antikörper (N-Term)

NLRC4 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855371
  • Target Alle NLRC4 Antikörper anzeigen
    NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
    Bindungsspezifität
    • 9
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 38
    • 15
    • 6
    • 2
    Human
    Wirt
    • 26
    • 10
    • 2
    Kaninchen
    Klonalität
    • 27
    • 11
    Polyklonal
    Konjugat
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NLRC4 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 17
    • 11
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human
    Produktmerkmale
    Rabbit Polyclonal antibody to CARD12 (NLR family, CARD domain containing 4)
    CARD12 antibody [N1], N-term
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the N-terminus region of human CARD12. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    WB: 1:500-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: MCF-7 , human NLRC4-transfected 293T cells

    Validation: Overexpression

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
    Andere Bezeichnung
    NLR family CARD domain containing 4 (NLRC4 Produkte)
    Synonyme
    CARD12 antikoerper, CLAN antikoerper, CLAN1 antikoerper, CLANA antikoerper, CLANB antikoerper, CLANC antikoerper, CLAND antikoerper, CLR2.1 antikoerper, IPAF antikoerper, 9530011P19Rik antikoerper, Card12 antikoerper, NLR family CARD domain containing 4 antikoerper, NLR family, CARD domain containing 4 antikoerper, NLRC4 antikoerper, Nlrc4 antikoerper
    Hintergrund
    In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]

    Cellular Localization: Cytoplasm
    Molekulargewicht
    116 kDa
    Gen-ID
    58484
    UniProt
    Q9NPP4
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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