CARD8 Antikörper (C-Term)

Produktnummer ABIN2855381

Produktdetails anti-CARD8 Antikörper

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Kreuzreaktivität: Human

Produktmerkmale: Rabbit polyclonal antibody to CARD8 (caspase recruitment domain family, member 8)
CARD8 antibody [N3C3]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human CARD8. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A431 , HepG2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Andere Bezeichnung: caspase recruitment domain family member 8 (CARD8 Produkte)

Synonyme: CARD8 antikoerper, CARDINAL antikoerper, DACAR antikoerper, DAKAR antikoerper, NDPP antikoerper, NDPP1 antikoerper, TUCAN antikoerper, caspase recruitment domain family, member 8 antikoerper, caspase recruitment domain-containing protein 8 antikoerper, caspase recruitment domain family member 8 antikoerper, CARD8 antikoerper, LOC718594 antikoerper

Hintergrund: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.

Cellular Localization: Cytoplasm , Nucleus

Molekulargewicht: 49 kDa

Gen-ID: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity