p63 Antikörper

Produktnummer ABIN2855394

Dieses Anti-p63-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von p63 in WB, ICC, IF, IP, IHC (p), IHC (fro) und PLA. Geeignet für Human. Dieses Primary Antibody wurde in 8+ Publikationen zitiert.

Kurzübersicht für p63 Antikörper (ABIN2855394)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p63 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Proximity Ligation Assay (PLA)

Güteklasse: KO Validated

Produktdetails anti-p63 Antikörper

Kreuzreaktivität: Hund, Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to p63 (tumor protein p63)
p63 antibody [N2C1], Internal

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human p63. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: mouse brain , rat brain , A431

Validation: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.58 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-p63 Antikörper (ABIN2855394)

Kim, Dollé, Vermeij, Gyenis, Vogel, Hoeijmakers, Wiley, Davalos, Hasty, Desprez, Campisi: "Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin." in: Aging cell, Vol. 19, Issue 3, pp. e13072, (2020) (PubMed).

Li, Wang, Torkelson, Shankar, Pattison, Zhen, Fang, Duren, Xin, Gaddam, Melo, Piekos, Li, Liaw, Chen, Li, Wernig, Wong, Chang, Oro: "TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment." in: Cell stem cell, Vol. 24, Issue 2, pp. 271-284.e8, (2020) (PubMed).

Jiang, Zhu, He, Gao, Tian, Ma, Wu, Das, Severinov, Hitzeroth, Debata, Liu, Zou, Shi, Xu, Wang, Bao, Ka-Kit, You, Cui, Hu: "Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women." in: Translational oncology, Vol. 12, Issue 7, pp. 959-967, (2019) (PubMed).

Montoro, Haber, Biton, Vinarsky, Lin, Birket, Yuan, Chen, Leung, Villoria, Rogel, Burgin, Tsankov, Waghray, Slyper, Waldman, Nguyen, Dionne, Rozenblatt-Rosen, Tata, Mou, Shivaraju, Bihler, Mense et al.: "A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. ..." in: Nature, Vol. 560, Issue 7718, pp. 319-324, (2019) (PubMed).

Xiong, Ren, Chen, Liu, Huang, Zhang, Odera, Chen, Kist, Peters, Garman, Sun, Chen: "PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium." in: The Journal of pathology, Vol. 244, Issue 2, pp. 164-175, (2019) (PubMed).

OBrien, Dorsey, Hannan, Hultgren: "Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner." in: PLoS pathogens, Vol. 14, Issue 12, pp. e1007457, (2019) (PubMed).

Reneker, Wang, Irlmeier, Huang: "Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse." in: Investigative ophthalmology & visual science, Vol. 58, Issue 5, pp. 2638-2646, (2017) (PubMed).

OBrien, Hannan, Yu, Livny, Roberson, Schwartz, Souza, Mendelsohn, Colonna, Lewis, Hultgren: "A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease." in: Nature microbiology, Vol. 2, pp. 16196, (2016) (PubMed).

Details zu p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Andere Bezeichnung: tumor protein p63

Hintergrund: This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Cellular Localization: Nucleus

Molekulargewicht: 77 kDa

Gen-ID: 8626

UniProt: Q9H3D4