VEGFA Antikörper (C-Term)

Produktnummer ABIN2855448

Dieses Anti-VEGFA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VEGFA in WB, IHC, ELISA und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 6+ Publikationen zitiert.

Kurzübersicht für VEGFA Antikörper (C-Term) (ABIN2855448)

Target: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VEGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-VEGFA Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to VEGF (vascular endothelial growth factor A)
VEGF antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human VEGF. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.17 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-VEGFA Antikörper (ABIN2855448)

Chen, Guo, Guo, Kong, Bai, Long: "Protective Effect of Vitamin C against Infancy Rat Corneal Injury Caused by Acute UVB Irradiation." in: BioMed research international, Vol. 2020, pp. 8089273, (2020) (PubMed).

Long, Yan, He, Zhang, Wang, Li, Xue, Chen, An, Zhang: "Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression." in: BMC ophthalmology, Vol. 19, Issue 1, pp. 112, (2019) (PubMed).

Chen, Wang, Wei, Tzeng, Lan, Cheng, Kuo: "Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal Cancer." in: Cancers, Vol. 11, Issue 8, (2019) (PubMed).

Toraih, Ibrahiem, Fawzy, Hussein, Al-Qahtani, Shaalan: "MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 3269379, (2018) (PubMed).

Kumarasamy, Sun: "Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative." in: International journal of oncology, Vol. 51, Issue 1, pp. 145-157, (2018) (PubMed).

Jiang, Li, Li, Fang, Long: "Dickkopf‑related protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 4959-66, (2016) (PubMed).

Details zu VEGFA

Target: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Andere Bezeichnung: vascular endothelial growth factor A

Hintergrund: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Cellular Localization: Secreted

Molekulargewicht: 27 kDa

Gen-ID: 7422

UniProt: P15692

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling