IL-10RA Antikörper
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- Target Alle IL-10RA (IL10RA) Antikörper anzeigen
- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IL-10RA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Human, Maus
- Produktmerkmale
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Rabbit Polyclonal antibody to IL10 Receptor alpha (interleukin 10 receptor, alpha)
IL10 Receptor alpha antibody - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human IL10 Receptor alpha. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product IL10RA Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Validation:Orthogonal, Overexpression
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.85 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
- Andere Bezeichnung
- interleukin 10 receptor subunit alpha (IL10RA Produkte)
- Hintergrund
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The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Cellular Localization: Membrane, Single-pass type I membrane protein - Molekulargewicht
- 63 kDa
- Gen-ID
- 3587
- UniProt
- Q13651
- Pathways
- Growth Factor Binding
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