SART1 Antikörper (Internal Region)

Produktnummer ABIN2855616

Produktdetails anti-SART1 Antikörper

Target: SART1 (Squamous Cell Carcinoma Antigen Recognized By T Cells (SART1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SART1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Produktmerkmale: Rabbit Polyclonal antibody to SART1 (squamous cell carcinoma antigen recognized by T cells)
SART1 antibody [N2C1], Internal

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human SART1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:1000-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:1000-1:10000*

Kommentare:

Conjugation Note: MH

Positive Control: Jurkat , Raji , K562 , THP-1 , HL-60 , NCI-H929 , NIH-3T3 , JC , BCL-1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.76 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu SART1

Target: SART1 (Squamous Cell Carcinoma Antigen Recognized By T Cells (SART1))

Andere Bezeichnung: SART1 (SART1 Produkte)

Synonyme: Dmel\\CG6686 antikoerper, SART1 antikoerper, MGC53679 antikoerper, MGC132129 antikoerper, zgc:91927 antikoerper, Ara1 antikoerper, HOMS1 antikoerper, SART1259 antikoerper, SNRNP110 antikoerper, Snu66 antikoerper, U5-110K antikoerper, CG6686 gene product from transcript CG6686-RB antikoerper, SART1, U4/U6.U5 tri-snRNP-associated protein 1 S homeolog antikoerper, SART1, U4/U6.U5 tri-snRNP-associated protein 1 antikoerper, squamous-cell carcinoma T-cell-recognized antigen antikoerper, squamous cell carcinoma antigen recognized by T cells 1 antikoerper, CG6686 antikoerper, sart1.S antikoerper, sart1 antikoerper, SART1 antikoerper, Sart1 antikoerper

Hintergrund: This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation, its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Cellular Localization: Nucleus

Molekulargewicht: 90 kDa

Gen-ID: 9092

Pathways: Ribonucleoprotein Complex Subunit Organization