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c-MYC Antikörper (Center)

MYC Reaktivität: Human, Maus WB, IF, IP, ICC, ChIP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855631
  • Highlights
    • High quality c-MYC Primärantikörper for the detection of MYC.
    • Reliable product with high standard validation data
    Target Alle c-MYC (MYC) Antikörper anzeigen
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Bindungsspezifität
    • 57
    • 48
    • 45
    • 39
    • 24
    • 22
    • 17
    • 15
    • 15
    • 14
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 373
    • 179
    • 133
    • 16
    • 15
    • 13
    • 13
    • 13
    • 10
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 294
    • 97
    • 7
    • 5
    • 2
    • 1
    Kaninchen
    Klonalität
    • 291
    • 114
    Polyklonal
    Konjugat
    • 196
    • 31
    • 25
    • 24
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser c-MYC Antikörper ist unkonjugiert
    Applikation
    • 295
    • 145
    • 102
    • 80
    • 76
    • 60
    • 53
    • 28
    • 26
    • 19
    • 14
    • 14
    • 12
    • 11
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)
    Kreuzreaktivität
    Schimpanse
    Kreuzreaktivität (Details)
    Chimpanzee (100 %)
    Produktmerkmale
    Rabbit Polyclonal antibody to c-Myc (v-myc myelocytomatosis viral oncogene homolog (avian))
    c-Myc antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human c-Myc. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product MYC Primärantikörper
    Produktspezifische Information
    What can the c-MYC Antibody ABIN2855631 be used for?
    This polyclonal c-MYC Antibody detects c-MYC. The c-MYC Antibody has been validated for various applications and can be used for the detection of c-MYC and derivatives by Western Blotting, Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Chromatin Immunoprecipitation.
    What validation data is available for this c-MYC Antibody?
    The Primärantikörper is referenced in 5 publications and is characterized by a proven, very high reliability. It has currently 8 product images that show its performance in a variety of applications. The product is currently available in 100 μL quantity. c-MYC Antibody for the detection of c-MYC and derivatives.
    What is the function of c-MYC?
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].
  • Applikationshinweise
    Suggested dilution Reference ChIP assay Assay-dependent dilution ICC/IF 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceChIP assayAssay-dependent dilution ICC/IF1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*
    Kommentare

    Positive Control: 293T , NIH-3T3 , Raw264.7 , HeLa , HeLa nuclear extract

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    1XPBS, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Chen, Ding, Chen, Hu, Lu, Wu, Zhang, Yang, Wu, Peng, Xie, Zhou, Wu, Zheng: "ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis." in: Oncogenesis, Vol. 9, Issue 4, pp. 42, (2020) (PubMed).

    Seira, Yamagata, Fukushima, Araki, Kurata, Yanagisawa, Mashimo, Nakamura, Regan, Murayama, Fujino: "Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region." in: Pharmacology research & perspectives, Vol. 6, Issue 6, pp. e00441, (2019) (PubMed).

    Ma, Wang, Chen, Li, Hur, Saijilafu: "Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development." in: Frontiers in molecular neuroscience, Vol. 10, pp. 391, (2017) (PubMed).

    Chung, Liu, Lin, Chi, Huang, Yang, Yeh, Tan, Lin: "ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance." in: Oncotarget, Vol. 7, Issue 16, pp. 22448-59, (2017) (PubMed).

    Wu, Lee, Hua, Kuo, Lin: "Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway." in: PLoS ONE, Vol. 10, Issue 7, pp. e0134122, (2016) (PubMed).

  • Target
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Andere Bezeichnung
    C-Myc (MYC Produkte)
    Synonyme
    MRTL antikoerper, MYCC antikoerper, bHLHe39 antikoerper, c-Myc antikoerper, CMYC antikoerper, c-myc antikoerper, C-MYC antikoerper, LOC100136746 antikoerper, ARC antikoerper, B430311C09Rik antikoerper, MYC antikoerper, NOP antikoerper, Nop30 antikoerper, RNCMYC antikoerper, mMyc antikoerper, AU016757 antikoerper, Myc2 antikoerper, Niard antikoerper, Nird antikoerper, cmyc antikoerper, zc-myc antikoerper, c-myc II antikoerper, myc-B antikoerper, myc2 antikoerper, myc1 antikoerper, CMyc antikoerper, zgc:55680 antikoerper, CG10798 antikoerper, D-Myc antikoerper, DM antikoerper, DMYc antikoerper, Dm antikoerper, Dmel\CG10798 antikoerper, Dmyc antikoerper, EG:BACN5I9.1 antikoerper, anon-WO03040301.171 antikoerper, bHLHe57 antikoerper, c-MYC antikoerper, d-myc antikoerper, dMYC antikoerper, dMyc antikoerper, dMyc1 antikoerper, da antikoerper, dm antikoerper, dm/dMyc antikoerper, dm/myc antikoerper, dmyc antikoerper, dmyc1 antikoerper, l(1)G0139 antikoerper, l(1)G0354 antikoerper, l(1)G0359 antikoerper, myc antikoerper, MYC proto-oncogene, bHLH transcription factor antikoerper, v-myc myelocytomatosis viral oncogene homolog antikoerper, nucleolar protein 3 (apoptosis repressor with CARD domain) antikoerper, myelocytomatosis oncogene antikoerper, MYC proto-oncogene, bHLH transcription factor a antikoerper, MYC proto-oncogene, bHLH transcription factor L homeolog antikoerper, MYC proto-oncogene, bHLH transcription factor S homeolog antikoerper, v-myc myelocytomatosis viral oncogene homolog (avian) antikoerper, MYC proto-oncogene, bHLH transcription factor b antikoerper, CG10798 gene product from transcript CG10798-RB antikoerper, MYC antikoerper, LOC100136746 antikoerper, Nol3 antikoerper, Myc antikoerper, myca antikoerper, myc.L antikoerper, myc.S antikoerper, mycb antikoerper
    Hintergrund
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

    Cellular Localization: Nucleus
    Molekulargewicht
    49 kDa
    Gen-ID
    4609
    Pathways
    p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt
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