EPAS1 Antikörper

Produktnummer ABIN2855683

Produktdetails anti-EPAS1 Antikörper

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Kreuzreaktivität: Human, Zebrafisch (Danio rerio)

Produktmerkmale: Rabbit Polyclonal antibody to HIF2 alpha (endothelial PAS domain protein 1)
HIF2 alpha antibody [N1N3]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human HIF2 alpha. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HepG2 (1% O2 treatment for 24hr)

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-EPAS1 Antikörper (ABIN2855683)

Ko, Tsai, Tseng, Cheng, Huang, Wu, Chung, Hsieh, Sun, Hwang, Yuh, Huang, Pai, Tzou, Hu: "Integration of CNS survival and differentiation by HIF2α." in: Cell death and differentiation, Vol. 18, Issue 11, pp. 1757-70, (2012) (PubMed).

Details zu EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Andere Bezeichnung: endothelial PAS domain protein 1 (EPAS1 Produkte)

Hintergrund: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

Cellular Localization: Nucleus

Molekulargewicht: 96 kDa

Gen-ID: 2034

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt