HSD17B4 Antikörper

Produktnummer ABIN2855717

Produktdetails anti-HSD17B4 Antikörper

Target: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD17B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to HSD17B4 (hydroxysteroid (17-beta) dehydrogenase 4)
HSD17B4 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human HSD17B4. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Rat heart

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-HSD17B4 Antikörper (ABIN2855717)

Frasinyuk, Zhang, Wyrebek, Yu, Xu, Sviripa, Bondarenko, Xie, Ngo, Morris, Mohler, Fiandalo, Watt, Liu: "Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)." in: Organic & biomolecular chemistry, Vol. 15, Issue 36, pp. 7623-7629, (2018) (PubMed).

Details zu HSD17B4

Target: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Andere Bezeichnung: hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4 Produkte)

Synonyme: zgc:55545 antikoerper, zgc:77300 antikoerper, CG3415 antikoerper, DmMFE-2 antikoerper, Dmel\\CG3415 antikoerper, MFE-2 antikoerper, DBP antikoerper, MPF-2 antikoerper, PRLTS1 antikoerper, SDR8C1 antikoerper, 17-beta-HSD antikoerper, 17[b]-HSD antikoerper, 4 antikoerper, MFP2 antikoerper, Mfp-2 antikoerper, perMFE-2 antikoerper, hydroxysteroid (17-beta) dehydrogenase 4 antikoerper, hydroxysteroid 17-beta dehydrogenase 4 antikoerper, peroxisomal Multifunctional enzyme type 2 antikoerper, hsd17b4 antikoerper, HSD17B4 antikoerper, Mfe2 antikoerper, Hsd17b4 antikoerper

Hintergrund: The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.

Cellular Localization: Peroxisome

Molekulargewicht: 80 kDa

Gen-ID: 3295

UniProt: P51659

Pathways: Monocarboxylic Acid Catabolic Process