PON2 Antikörper

Produktnummer ABIN2855759

Produktdetails anti-PON2 Antikörper

Target: PON2 (Paraoxonase 2 (PON2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PON2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to PON2 (paraoxonase 2)
PON2 antibody [N1C2]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PON2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A431 , Mouse liver

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-PON2 Antikörper (ABIN2855759)

Devarajan, Su, Grijalva, Yalamanchi, Yalamanchi, Gao, Trost, Nwokedi, Farias-Eisner, Farias-Eisner, Fogelman, Reddy: "Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer." in: Cell death & disease, Vol. 9, Issue 3, pp. 392, (2019) (PubMed).

Details zu PON2

Target: PON2 (Paraoxonase 2 (PON2))

Andere Bezeichnung: paraoxonase 2 (PON2 Produkte)

Synonyme: PON2 antikoerper, pon1 antikoerper, MGC53915 antikoerper, pon2 antikoerper, 6330405I24Rik antikoerper, AI481612 antikoerper, serum paraoxonase/arylesterase 2 antikoerper, paraoxonase 2 antikoerper, paraoxonase 2 L homeolog antikoerper, Serum paraoxonase/arylesterase 2 antikoerper, LOC100303695 antikoerper, PON2 antikoerper, pon2.L antikoerper, BDBG_00600 antikoerper, pon2 antikoerper, Pon2 antikoerper

Hintergrund: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Cellular Localization: Membrane, Peripheral membrane protein

Molekulargewicht: 39 kDa

Gen-ID: 5445

UniProt: Q15165