ETS2 Antikörper (Center)
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- Target Alle ETS2 Antikörper anzeigen
- ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))
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Bindungsspezifität
- Center
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ETS2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC)
- Produktmerkmale
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Rabbit Polyclonal antibody to ETS2 (v-ets erythroblastosis virus E26 oncogene homolog 2 (avian))
ETS2 antibody - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human ETS2. The exact sequence is proprietary.
- Isotyp
- IgG
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- Applikationshinweise
- Suggested dilution Reference ChIP assay Assay-dependent dilution ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceChIP assayAssay-dependent dilution ICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*
- Kommentare
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Positive Control: HeLa
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- 1XPBS, 1 % BSA, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma." in: PLoS genetics, Vol. 15, Issue 7, pp. e1008250, (2019) (PubMed).
: "Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma." in: Cancer research, Vol. 77, Issue 23, pp. 6614-6626, (2018) (PubMed).
: "Functional dissection of breast cancer risk-associated TERT promoter variants." in: Oncotarget, Vol. 8, Issue 40, pp. 67203-67217, (2017) (PubMed).
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Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma." in: PLoS genetics, Vol. 15, Issue 7, pp. e1008250, (2019) (PubMed).
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- Target
- ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))
- Andere Bezeichnung
- ETS2 (ETS2 Produkte)
- Synonyme
- 0123/09 antikoerper, 0608/07 antikoerper, 0998/12 antikoerper, 3520 antikoerper, CG17077 antikoerper, CG8705 antikoerper, D-Ets-2 antikoerper, D-ets-2 antikoerper, DMPOINT1A antikoerper, Dmel\\CG17077 antikoerper, E(E2F)3D antikoerper, EK3-2 antikoerper, ETS2 antikoerper, EY3-1 antikoerper, Ets antikoerper, Ets2 antikoerper, Ets58AB antikoerper, Ets94F antikoerper, PNT-P1 antikoerper, PNTP1 antikoerper, PNTP2 antikoerper, POINT antikoerper, Pnt antikoerper, Pnt-P1 antikoerper, PntP1 antikoerper, PntP2 antikoerper, Pointed-P1 antikoerper, ets94F antikoerper, l(3)07825 antikoerper, l(3)j1B7 antikoerper, l(3)s118306 antikoerper, png antikoerper, pnt-P1 antikoerper, pnt-P2 antikoerper, pntP2 antikoerper, pntegfr antikoerper, pointed-RC antikoerper, ptd antikoerper, zgc:92106 antikoerper, wu:fe02h08 antikoerper, wu:fk74c05 antikoerper, AU022856 antikoerper, Ets-2 antikoerper, ETS2IT1 antikoerper, c-ets-2 antikoerper, pointed antikoerper, v-ets avian erythroblastosis virus E26 oncogene homolog 2 antikoerper, E26 avian leukemia oncogene 2, 3' domain antikoerper, ETS proto-oncogene 2, transcription factor antikoerper, pnt antikoerper, ets2 antikoerper, Ets2 antikoerper, ETS2 antikoerper
- Hintergrund
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ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]
Cellular Localization: Nucleus - Molekulargewicht
- 53 kDa
- Gen-ID
- 2114
- Pathways
- EGFR Signaling Pathway, Myometrial Relaxation and Contraction
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