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Dystroglycan Antikörper

DAG1 Reaktivität: Human WB, ICC, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2856020
  • Target Alle Dystroglycan (DAG1) Antikörper anzeigen
    Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
    Reaktivität
    • 37
    • 22
    • 20
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 50
    • 4
    • 2
    • 1
    Kaninchen
    Klonalität
    • 53
    • 4
    Polyklonal
    Konjugat
    • 22
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Dystroglycan Antikörper ist unkonjugiert
    Applikation
    • 44
    • 23
    • 21
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Kreuzreaktivität
    Pferd, Human, Maus, Ratte
    Produktmerkmale
    Rabbit Polyclonal antibody to alpha Dystroglycan (dystroglycan 1 (dystrophin-associated glycoprotein 1))
    DAG1 antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human DAG1. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product DAG1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: U87-MG membrane fraction extract , MCF-7 membrane extracts , 293T membrane extracts

    Validation: Orthogonal

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.21 mg/mL
    Buffer
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Jae, Raaben, Herbert, Kuehne, Wirchnianski, Soh, Stubbs, Janssen, Damme, Saftig, Whelan, Dye, Brummelkamp: "Virus entry. Lassa virus entry requires a trigger-induced receptor switch." in: Science (New York, N.Y.), Vol. 344, Issue 6191, pp. 1506-10, (2014) (PubMed).

  • Target
    Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))
    Andere Bezeichnung
    dystroglycan 1 (DAG1 Produkte)
    Synonyme
    LOC398500 antikoerper, dag1 antikoerper, MGC53537 antikoerper, 156DAG antikoerper, A3a antikoerper, AGRNR antikoerper, DAG antikoerper, MDDGC7 antikoerper, MDDGC9 antikoerper, DAG1 antikoerper, RAB7 antikoerper, dg antikoerper, a3a antikoerper, dag antikoerper, agrnr antikoerper, 156dag antikoerper, D9Wsu13e antikoerper, DG antikoerper, Dp427 antikoerper, Dp71 antikoerper, CG18250 antikoerper, CT41273 antikoerper, DmDG antikoerper, Dmel\\CG18250 antikoerper, atu antikoerper, dgn antikoerper, dys antikoerper, GB14967 antikoerper, APOJ antikoerper, CLI antikoerper, RATTRPM2B antikoerper, SGP-2 antikoerper, SGP2 antikoerper, SP-40 antikoerper, SP40 antikoerper, TRPM-2 antikoerper, TRPM2B antikoerper, Trpm2 antikoerper, Trpmb antikoerper, Ala-1 antikoerper, H9/25 antikoerper, Ly-27 antikoerper, Ly-6 antikoerper, Ly27 antikoerper, wu:fb83d06 antikoerper, wu:fi25f06 antikoerper, wu:fi37b08 antikoerper, zgc:109786 antikoerper, DystroGlycaN antikoerper, dystroglycan 1 L homeolog antikoerper, dystroglycan 1 antikoerper, dystroglycan 1 S homeolog antikoerper, Dystroglycan antikoerper, dystroglycan antikoerper, clusterin antikoerper, lymphocyte antigen 6 complex antikoerper, dgn-1 antikoerper, dag1.L antikoerper, dgn-2 antikoerper, dgn-3 antikoerper, DAG1 antikoerper, dag1.S antikoerper, Dag1 antikoerper, dag1 antikoerper, Dg antikoerper, LOC408826 antikoerper, Clu antikoerper, Ly6 antikoerper
    Hintergrund
    Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.

    Cellular Localization: Alpha-dystroglycan: Secreted , extracellular space , Beta-dystroglycan: Cell membrane , Cytoplasm , cytoskeleton
    Molekulargewicht
    97 kDa
    Gen-ID
    1605
    UniProt
    Q14118
    Pathways
    Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
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