BCL2L1 Antikörper
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- Target Alle BCL2L1 Antikörper anzeigen
- BCL2L1 (BCL2-Like 1 (BCL2L1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser BCL2L1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Kreuzreaktivität
- Hund, Human, Maus, Ratte
- Produktmerkmale
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Rabbit Polyclonal antibody to Bcl-X (BCL2-like 1)
Bcl-X antibody - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human Bcl-X. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product BCL2L1 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: NIH-3T3 , PC-12
Validation: Orthogonal
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.45 mg/mL
- Buffer
- 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction." in: FEBS letters, Vol. 589, Issue 23, pp. 3581-7, (2016) (PubMed).
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Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction." in: FEBS letters, Vol. 589, Issue 23, pp. 3581-7, (2016) (PubMed).
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- Target
- BCL2L1 (BCL2-Like 1 (BCL2L1))
- Andere Bezeichnung
- BCL2 like 1 (BCL2L1 Produkte)
- Synonyme
- BCL-XL/S antikoerper, BCL2L antikoerper, BCLX antikoerper, BCLXL antikoerper, BCLXS antikoerper, Bcl-X antikoerper, PPP1R52 antikoerper, bcl-xL antikoerper, bcl-xS antikoerper, Bcl(X)L antikoerper, Bcl-XL antikoerper, Bcl-Xs antikoerper, Bcl2l antikoerper, BclX antikoerper, bcl-x antikoerper, Bcl-xl antikoerper, Bclx antikoerper, bcl-X antikoerper, Bcl-xL antikoerper, BCL-XL antikoerper, BCL2L1 antikoerper, bcl-XL antikoerper, bcl-x(l) antikoerper, bcl-xl/s antikoerper, bcl-xs antikoerper, bcl2l antikoerper, bclx antikoerper, bclxl antikoerper, xR11 antikoerper, bcl-xl antikoerper, blp1 antikoerper, cb1021 antikoerper, zfBLP1 antikoerper, BCL2 like 1 antikoerper, BCL2-like 1 antikoerper, Bcl2-like 1 antikoerper, BCL2-like 1 L homeolog antikoerper, bcl2-like 1 antikoerper, BCL2L1 antikoerper, Bcl2l1 antikoerper, bcl2l1 antikoerper, bcl2l1.L antikoerper
- Hintergrund
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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Cellular Localization: Mitochondrion membrane, Single-pass membrane protein , Nucleus membrane, Single-pass membrane protein, Cytoplasmic side , Mitochondrion membrane , Nucleus membrane - Molekulargewicht
- 26 kDa
- Gen-ID
- 598
- UniProt
- Q07817
- Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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