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LAMa4 Antikörper (C-Term)

LAMa4 Reaktivität: Human IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2856262
  • Target Alle LAMa4 Antikörper anzeigen
    LAMa4 (Laminin, alpha 4 (LAMa4))
    Bindungsspezifität
    • 15
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 50
    • 12
    • 1
    Human
    Wirt
    • 48
    • 8
    • 1
    • 1
    Kaninchen
    Klonalität
    • 52
    • 6
    Polyklonal
    Konjugat
    • 25
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LAMa4 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 14
    • 13
    • 13
    • 12
    • 7
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Maus
    Produktmerkmale
    Rabbit Polyclonal antibody to Laminin alpha 4 (laminin, alpha 4)
    Laminin alpha 4 antibody [C3], C-term
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human Laminin alpha 4. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product LAMa4 Primärantikörper
  • Applikationshinweise
    IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.74 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    LAMa4 (Laminin, alpha 4 (LAMa4))
    Andere Bezeichnung
    laminin subunit alpha 4 (LAMa4 Produkte)
    Synonyme
    si:dkey-119m7.3 antikoerper, si:busm1-189a20.2 antikoerper, CMD1JJ antikoerper, LAMA3 antikoerper, LAMA4*-1 antikoerper, RGD1560062 antikoerper, laminin subunit alpha 4 antikoerper, laminin, alpha 4 antikoerper, LAMA4 antikoerper, lama4 antikoerper, Lama4 antikoerper
    Hintergrund
    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    Cellular Localization: Secreted , extracellular space , extracellular matrix , basement membrane
    Molekulargewicht
    203 kDa
    Gen-ID
    3910
    UniProt
    Q16363
    Pathways
    Brown Fat Cell Differentiation
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