HNRNPA1 Antikörper

Produktnummer ABIN2856277

Produktdetails anti-HNRNPA1 Antikörper

Target: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNRNPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1)
hnRNP A1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Güteklasse: KO Validated

Immunogen: Recombinant protein encompassing a sequence within the center region of human hnRNP A1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: H1299 , HeLaS3 , Mouse brain , PC-12 , 293T

Validation: KO/KD

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.46 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu HNRNPA1

Target: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Andere Bezeichnung: heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1 Produkte)

Synonyme: HNRPA1 antikoerper, HNRPA1L3 antikoerper, hnRNP A1 antikoerper, hnRNP-A1 antikoerper, hnrpa1 antikoerper, TPT1P antikoerper, HNRNPA1 antikoerper, D15Ertd119e antikoerper, Hdp antikoerper, Hnrpa1 antikoerper, hnrnp-A1 antikoerper, ROA1 antikoerper, zgc:66127 antikoerper, heterogeneous nuclear ribonucleoprotein A1 antikoerper, heterogeneous nuclear ribonucleoprotein A1b antikoerper, Heterogeneous nuclear ribonucleoprotein A1 antikoerper, heterogeneous nuclear ribonucleoprotein A1 S homeolog antikoerper, ribonucleoprotein A1a antikoerper, heterogeneous nuclear ribonucleoprotein A1-like antikoerper, heterogeneous nuclear ribonucleoprotein A1a antikoerper, HNRNPA1 antikoerper, hnrnpa1b antikoerper, LOC100101226 antikoerper, roa1 antikoerper, Hnrnpa1 antikoerper, hnrnpa1.S antikoerper, hnrnpa1 antikoerper, LOC100359118 antikoerper, hnrnpa1a antikoerper

Hintergrund: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.

Cellular Localization: Nucleus , Cytoplasm

Molekulargewicht: 39 kDa

Gen-ID: 3178

UniProt: P09651