RANGAP1 Antikörper (N-Term)

Produktnummer ABIN2856335

Produktdetails anti-RANGAP1 Antikörper

Target: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RANGAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human

Produktmerkmale: Rabbit Polyclonal antibody to RanGAP1 (Ran GTPase activating protein 1)
RanGAP1 antibody [N1], N-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RanGAP1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A431

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu RANGAP1

Target: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Andere Bezeichnung: Ran GTPase activating protein 1 (RANGAP1 Produkte)

Synonyme: Fug1 antikoerper, RANGAP antikoerper, SD antikoerper, ATRANGAP1 antikoerper, RAN GTPASE-ACTIVATING PROTEIN 1 antikoerper, RAN GTPase activating protein 1 antikoerper, RanGAP1 antikoerper, fug1 antikoerper, rangap1b antikoerper, rna1p antikoerper, C79654 antikoerper, mKIAA1835 antikoerper, rangap1 antikoerper, rangap1a antikoerper, Protein rna1 antikoerper, CG9999 antikoerper, CT28175 antikoerper, Dmel\CG9999 antikoerper, RGP1_DROME antikoerper, Ran antikoerper, RanGAP antikoerper, RanGap antikoerper, RanGap1 antikoerper, Scl antikoerper, Sd antikoerper, Sd-RanGAP antikoerper, Sd-RanGap antikoerper, dRanGAP antikoerper, ranGAP antikoerper, ranGap antikoerper, rangap antikoerper, zgc:154097 antikoerper, Ran GTPase activating protein 1 antikoerper, RAN GTPase activating protein 1 antikoerper, ran GTPase activating protein 1 antikoerper, Ran GTPase activating protein 1 S homeolog antikoerper, Ran GTPase activating protein 1 L homeolog antikoerper, Ran GAP Rna1 antikoerper, Ran GTPase activating protein antikoerper, RAN GTPase activating protein 1a antikoerper, RANGAP1 antikoerper, TERG_02084 antikoerper, rangap1.S antikoerper, Rangap1 antikoerper, rangap1.L antikoerper, rna1 antikoerper, RanGAP antikoerper, rangap1a antikoerper

Hintergrund: RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88 % identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Cellular Localization: Cytoplasm , Nucleus membrane, Peripheral membrane protein, Cytoplasmic side , Kinetochore (By similarity)

Molekulargewicht: 64 kDa

Gen-ID: 5905

UniProt: P46060

Pathways: M Phase, Protein targeting to Nucleus