SKP1 Antikörper

Produktnummer ABIN2856416

Produktdetails anti-SKP1 Antikörper

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to SKP1 (S-phase kinase-associated protein 1)
SKP1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human SKP1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: NIH-3T3 , A549 , H1299 , HCT116 , MCF-7

Validation: Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu SKP1

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Andere Bezeichnung: S-phase kinase associated protein 1 (SKP1 Produkte)

Synonyme: EMC19 antikoerper, OCP-II antikoerper, OCP2 antikoerper, SKP1A antikoerper, TCEB1L antikoerper, p19A antikoerper, 15kDa antikoerper, 2610043E24Rik antikoerper, 2610206H23Rik antikoerper, SKP1 antikoerper, Tceb1l antikoerper, p19Skp1 antikoerper, Skp1a antikoerper, skp1a antikoerper, zgc:73186 antikoerper, ocp2 antikoerper, emc19 antikoerper, ocp-ii antikoerper, tceb1l antikoerper, ARABIDOPSIS SKP1 HOMOLOGUE 1 antikoerper, ASK1 antikoerper, ATSKP1 antikoerper, S phase kinase-associated protein 1 antikoerper, T4O12.17 antikoerper, T4O12_17 antikoerper, UFO INTERACTING PROTEIN 1 antikoerper, UIP1 antikoerper, ocp-2 antikoerper, S-phase kinase associated protein 1 antikoerper, S-phase kinase-associated protein 1 antikoerper, S-phase kinase-associated protein 1 pseudogene antikoerper, S-phase kinase-associated protein 1A antikoerper, S-phase kinase-associated protein 1 S homeolog antikoerper, S phase kinase-associated protein 1 antikoerper, SKP1 antikoerper, skp1 antikoerper, LOC100340043 antikoerper, Skp1a antikoerper, Skp1 antikoerper, skp1.S antikoerper

Hintergrund: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Molekulargewicht: 19 kDa

Gen-ID: 6500

UniProt: P63208

Pathways: Zellzyklus, Hedgehog Signalweg, Mitotic G1-G1/S Phases