CBFB Antikörper
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- Target Alle CBFB Antikörper anzeigen
- CBFB (Core-Binding Factor, beta Subunit (CBFB))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CBFB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Human
- Produktmerkmale
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Rabbit polyclonal antibody to v (core-binding factor, beta subunit)
CBFb antibody [N1C3] - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human CBFb. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product CBFB Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: 293T , Raji
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- CBFB (Core-Binding Factor, beta Subunit (CBFB))
- Andere Bezeichnung
- core-binding factor subunit beta (CBFB Produkte)
- Synonyme
- PEBP2B antikoerper, Cbfb antikoerper, pebp2b antikoerper, Pebp2 antikoerper, CBFB antikoerper, unp1266 antikoerper, cbf-beta antikoerper, cbfbeta antikoerper, pea2-beta antikoerper, pebp2-beta antikoerper, AI893578 antikoerper, PEA2 antikoerper, PEBP2b antikoerper, Pebpb2 antikoerper, core-binding factor beta subunit antikoerper, core binding factor beta subunit antikoerper, core-binding factor, beta subunit antikoerper, core-binding factor, beta subunit S homeolog antikoerper, core binding factor beta antikoerper, CBFB antikoerper, Cbfb antikoerper, cbfb antikoerper, cbfb.S antikoerper
- Hintergrund
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The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
Cellular Localization: Nucleus - Molekulargewicht
- 22 kDa
- Gen-ID
- 865
- UniProt
- Q13951
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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