UNC13D Antikörper (C-Term)

Produktnummer ABIN2856569

Produktdetails anti-UNC13D Antikörper

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNC13D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human

Produktmerkmale: Rabbit Polyclonal antibody to Munc 13-4 (unc-13 homolog D (C. elegans))
Munc 13-4 antibody [C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Munc 13-4. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Jurkat , K562

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu UNC13D

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Andere Bezeichnung: unc-13 homolog D (UNC13D Produkte)

Synonyme: FHL3 antikoerper, HLH3 antikoerper, HPLH3 antikoerper, Munc13-4 antikoerper, UNC13D antikoerper, 2610108D09Rik antikoerper, Jinx antikoerper, mFLJ00067 antikoerper, Unc13h4 antikoerper, BIGH3 antikoerper, CDB1 antikoerper, CDG2 antikoerper, CDGG1 antikoerper, CSD antikoerper, CSD1 antikoerper, CSD2 antikoerper, CSD3 antikoerper, EBMD antikoerper, LCD1 antikoerper, unc-13 homolog D antikoerper, unc-13 homolog D (C. elegans) antikoerper, transforming growth factor beta induced antikoerper, UNC13D antikoerper, Unc13d antikoerper, TGFBI antikoerper, unc13d antikoerper, un13d antikoerper

Hintergrund: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

Cellular Localization: Cytoplasm , Membrane, Peripheral membrane protein

Molekulargewicht: 123 kDa

Gen-ID: 201294

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process