ATP6V0A4 Antikörper (N-Term)

Produktnummer ABIN2856797

Produktdetails anti-ATP6V0A4 Antikörper

Target: ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP6V0A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus, Rind (Kuh)

Kreuzreaktivität (Details): Mouse (87 %), Bovine (82 %)

Produktmerkmale: Rabbit polyclonal antibody to V-ATPase 116 kDa isoform a4 (ATPase, H+ transporting, lysosomal V0 subunit a4)
V-ATPase 116 kDa isoform a4 antibody [N1N3-2]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human V-ATPase 116 kDa isoform a4. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Kommentare:

Positive Control: A431 , HeLa , HepG2 , Molt-4 , Raji

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu ATP6V0A4

Target: ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))

Andere Bezeichnung: V-ATPase 116 kDa Isoform a4 (ATP6V0A4 Produkte)

Synonyme: A4 antikoerper, ATP6N1B antikoerper, ATP6N2 antikoerper, RDRTA2 antikoerper, RTA1C antikoerper, RTADR antikoerper, STV1 antikoerper, VPH1 antikoerper, VPP2 antikoerper, Atp6n1b antikoerper, a4 antikoerper, ATPase H+ transporting V0 subunit a4 antikoerper, ATPase, H+ transporting, lysosomal V0 subunit A4 antikoerper, ATP6V0A4 antikoerper, Atp6v0a4 antikoerper

Hintergrund: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.

Cellular Localization: Apical cell membrane, Multi-pass membrane protein

Molekulargewicht: 96 kDa

Gen-ID: 50617

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Proton Transport