UVRAG Antikörper (Biotin)

Produktnummer ABIN2868821

Produktdetails anti-UVRAG Antikörper (Biotin)

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UVRAG Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Predicted molecular weight at ~78.1 kDa. Observed molecular weights in the 75-90 kDa range.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Peptide Affinity Purified

Immunogen: Synthetic peptide from the mid-protein of human UVRAG

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:1000 dilution of ABIN2868821 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Andere Bezeichnung: UVRAG (UVRAG Produkte)

Synonyme: DHTX antikoerper, VPS38 antikoerper, p63 antikoerper, 9530039D02Rik antikoerper, AI648770 antikoerper, BB124205 antikoerper, Uvrag1 antikoerper, Uvragl antikoerper, zgc:56164 antikoerper, uvrag antikoerper, MGC81810 antikoerper, UVRAG antikoerper, MGC131135 antikoerper, CG6116 antikoerper, Dmel\\CG6116 antikoerper, UV radiation resistance associated antikoerper, UV radiation resistance associated gene antikoerper, UV radiation resistance associated S homeolog antikoerper, UV radiation resistance associated L homeolog antikoerper, UV-resistance associated gene antikoerper, UVRAG antikoerper, Uvrag antikoerper, uvrag antikoerper, uvrag.S antikoerper, uvrag.L antikoerper

Hintergrund: UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.

Gen-ID: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5