RAGE Antikörper

Produktnummer ABIN289974

Produktdetails anti-RAGE Antikörper

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody was purified from rabbit serum by Protein G affinity chromatography.

Immunogen: Partial peptide of Human RAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.25 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Konservierungsmittel: ProClin

Lagerung: -20 °C

Details zu RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Andere Bezeichnung: RAGE (AGER Produkte)

Hintergrund: RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecularweight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been foundin several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand ofRAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE,N-carboxymethyllysine(CML),beta-amyloid and so on. The accumulation of AGEs-proteins invivo has been demonstrated in several disease, it is not clear whether AGEs-proteinsaccumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE isinvolved in pathophysiological function of diabetes and Alzheimer

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine