TNK2 Antikörper (AA 70-385)

Produktnummer ABIN3016190

Produktdetails anti-TNK2 Antikörper

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Bindungsspezifität: AA 70-385

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TGWLLELLSE VQLQQYFLRL RDDLNVTRLS HFEYVKNEDL EKIGMGRPGQ RRLWEAVKRR KALCKRKSWM SKVFSGKRLE AEFPPHHSQS TFRKTSPAPG GPAGEGPLQS LTCLIGEKDL RLLEKLGDGS FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT FSHASDTWMF GVTLWE

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 70-385 of human TNK2 (NP_001010938.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-TNK2 Antikörper (ABIN3016190)

Hu, Xu, Yin, Zhang, Lu, Wu, Xue, Ho, Gao, Zhao, Zhang: "Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded." in: Cell discovery, Vol. 2, pp. 15047, (2016) (PubMed).

Details zu TNK2

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Andere Bezeichnung: TNK2 (TNK2 Produkte)

Synonyme: ACK antikoerper, ACK-1 antikoerper, ACK1 antikoerper, p21cdc42Hs antikoerper, AW552477 antikoerper, Ack antikoerper, Cdgip antikoerper, Pyk1 antikoerper, ack1 antikoerper, ackb antikoerper, tnk2 antikoerper, tnk2b antikoerper, wu:fj16g04 antikoerper, zgc:154019 antikoerper, tyrosine kinase non receptor 2 antikoerper, tyrosine kinase, non-receptor, 2 antikoerper, tyrosine kinase, non-receptor, 1 antikoerper, TNK2 antikoerper, Tnk2 antikoerper, tnk1 antikoerper

Hintergrund: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.,TNK2,ACK,ACK-1,ACK1,p21cdc42Hs,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Cell Cycle,Growth factor,EGF,TNK2

Molekulargewicht: 60 kDa/114 kDa/119 kDa

Gen-ID: 10188

UniProt: Q07912