RUNX2 Antikörper (AA 242-521)

Produktnummer ABIN3016834

Produktdetails anti-RUNX2 Antikörper

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Bindungsspezifität: AA 242-521

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: FSDRLSDLGR IPHPSMRVGV PPQNPRPSLN SAPSPFNPQG QSQITDPRQA QSSPPWSYDQ SYPSYLSQMT SPSIHSTTPL SSTRGTGLPA ITDVPRRISD DDTATSDFCL WPSTLSKKSQ AGASELGPFS DPRQFPSISS LTESRFSNPR MHYPATFTYT PPVTSGMSLG MSATTHYHTY LPPPYPGSSQ SQSGPFQTSS TPYLYYGTSS GSYQFPMVPG GDRSPSRMLP PCTTTSNGST LLNPNLPNQN DGVDADGSHS SSPTVLNSSG RMDESVWRPY

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 242-521 of human RUNX2 (NP_001019801.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:1000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-RUNX2 Antikörper (ABIN3016834)

Zhang, Wang, Zeng, Yan, Ouyang, Liu, Sun, Zhao, Fang, Pan, Xie, Yang, Zhang, Bai, Cai: "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis." in: Osteoarthritis and cartilage, Vol. 25, Issue 6, pp. 952-963, (2018) (PubMed).

Gao, Li, Li: "Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway." in: American journal of translational research, Vol. 10, Issue 1, pp. 315-324, (2018) (PubMed).

Wang, Zhang, Sun, Wang, Yang, Yang, Zhang, Luo, Wang, Jiang, Zeng, Cai, Bai: "Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 25, Issue 3, pp. 715-727, (2017) (PubMed).

Li, Xu, Xing, Qian, Chen, Gu, Guo, Lai, Zhao, Li, Wang, Wang, Deng: "A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development." in: Scientific reports, Vol. 7, pp. 40505, (2017) (PubMed).

Wu, Wang, Ji, Ou, Xia, Zhang, Zhao: "C4orf7 modulates osteogenesis and adipogenesis of human periodontal ligament cells." in: American journal of translational research, Vol. 9, Issue 12, pp. 5708-5718, (2017) (PubMed).

Details zu RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Andere Bezeichnung: RUNX2 (RUNX2 Produkte)

Synonyme: AML3 antikoerper, CBF-alpha-1 antikoerper, CBFA1 antikoerper, CCD antikoerper, CCD1 antikoerper, CLCD antikoerper, OSF-2 antikoerper, OSF2 antikoerper, PEA2aA antikoerper, PEBP2aA antikoerper, Cbf antikoerper, Cbfa-1 antikoerper, Cbfa1 antikoerper, LS3 antikoerper, Osf2 antikoerper, Pebp2a1 antikoerper, Pebpa2a antikoerper, runx2 antikoerper, RUNX2 antikoerper, ccd antikoerper, aml3 antikoerper, ccd1 antikoerper, osf2 antikoerper, cbfa1 antikoerper, pea2aa antikoerper, pebp2a1 antikoerper, pebp2a2 antikoerper, pebp2aa antikoerper, pebp2aa1 antikoerper, runt related transcription factor 2 antikoerper, runt-related transcription factor 2a antikoerper, runt-related transcription factor 2 antikoerper, runt related transcription factor 2 L homeolog antikoerper, RUNX2 antikoerper, runx2a antikoerper, Runx2 antikoerper, runx2 antikoerper, LOC703331 antikoerper, LOC100549663 antikoerper, runx2.L antikoerper

Hintergrund: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.,RUNX2,AML3,CBF-alpha-1,CBFA1,CCD,CCD1,CLCD,OSF-2,OSF2,PEA2aA,PEBP2aA,Epigenetics & Nuclear Signaling,Transcription Factors,Cell Biology & Developmental Biology,Extracellular Matrix,Bone,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,Target gene,RUNX2

Molekulargewicht: 54 kDa/55 kDa/56 kDa

Gen-ID: 860

UniProt: Q13950