EIF4G2 Antikörper (AA 750-850)

Produktnummer ABIN3016941

Produktdetails anti-EIF4G2 Antikörper

Target: EIF4G2 (Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2))

Bindungsspezifität: AA 750-850

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF4G2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequenz: IYKWIKDNIS PKLHVDKGFV NILMTSFLQY ISSEVNPPSD ETDSSSAPSK EQLEQEKQLL LSFKPVMQKF LHDHVDLQVS ALYALQVHCY NSNFPKGMLL R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 750-850 of human EIF4G2 (NP_001409.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IHC,1:100 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu EIF4G2

Target: EIF4G2 (Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2))

Andere Bezeichnung: EIF4G2 (EIF4G2 Produkte)

Hintergrund: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3, eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.,EIF4G2,AAG1,DAP5,NAT1,P97,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,Apoptosis,EIF4G2

Molekulargewicht: 98 kDa/102 kDa

Gen-ID: 1982

UniProt: P78344