Perforin 1 Antikörper (AA 280-555)

Produktnummer ABIN3020642

Produktdetails anti-Perforin 1 Antikörper

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Bindungsspezifität: AA 280-555

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Perforin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: EEKKKKHKMT ASFHQTYRER HSEVVGGHHT SINDLLFGIQ AGPEQYSAWV NSLPGSPGLV DYTLEPLHVL LDSQDPRREA LRRALSQYLT DRARWRDCSR PCPPGRQKSP RDPCQCVCHG SAVTTQDCCP RQRGLAQLEV TFIQAWGLWG DWFTATDAYV KLFFGGQELR TSTVWDNNNP IWSVRLDFGD VLLATGGPLR LQVWDQDSGR DDDLLGTCDQ APKSGSHEVR CNLNHGHLKF RYHARCLPHL GGGTCLDYVP QMLLGEPPGN RSGAVW

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin (NP_001076585.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Andere Bezeichnung: PRF1 (PRF1 Produkte)

Synonyme: FLH2 antikoerper, HPLH2 antikoerper, P1 antikoerper, PFN1 antikoerper, PFP antikoerper, PRF1 antikoerper, Pfn antikoerper, Pfp antikoerper, Prf-1 antikoerper, Cyta antikoerper, RATCYTA antikoerper, LOC443187 antikoerper, perforin antikoerper, prf1 antikoerper, cytolysin antikoerper, perforin-1 antikoerper, perforin-1-like antikoerper, perforin 1 antikoerper, perforin 1 (pore forming protein) antikoerper, perforin antikoerper, perforin 1 L homeolog antikoerper, PRF1 antikoerper, Prf1 antikoerper, LOC443187 antikoerper, prf1 antikoerper, prf1.L antikoerper

Hintergrund: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.,PRF1,FLH2,HPLH2,P1,PFN1,PFP,perforin-1,Perforin,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,PRF1

Molekulargewicht: 61 kDa

Gen-ID: 5551

UniProt: P14222

Pathways: Apoptose, Caspase Kaskade in der Apoptose