DAXX Antikörper (AA 580-740)

Produktnummer ABIN302079

Produktdetails anti-DAXX Antikörper

Target: DAXX (Death-Domain Associated Protein (DAXX))

Bindungsspezifität: AA 580-740

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DAXX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Spezifität: The mouse monoclonal antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: His6-tagged protein corresponding to amino acids 580-740 of human Daxx.

Klon: DAXX-03

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blotting: Recommended dilution: 2 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-DAXX Antikörper (ABIN302079)

Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

Details zu DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Andere Bezeichnung: Daxx (DAXX Produkte)

Synonyme: BING2 antikoerper, DAP6 antikoerper, EAP1 antikoerper, LOC100226911 antikoerper, daxx antikoerper, si:dz179b20.7 antikoerper, wu:fd15c03 antikoerper, death domain associated protein antikoerper, Fas death domain-associated protein antikoerper, 28S ribosomal protein S29, mitochondrial antikoerper, death-domain associated protein antikoerper, death-associated protein 6 L homeolog antikoerper, DAXX antikoerper, Daxx antikoerper, LOC100226911 antikoerper, daxx.L antikoerper, daxx antikoerper

Hintergrund: Death domain associated protein,Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions both in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).,DAP6, EAP1, BING2

Gen-ID: 1616

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway