FAM3B Antikörper (AA 30-235)

Produktnummer ABIN3021391

Produktdetails anti-FAM3B Antikörper

Target: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Bindungsspezifität: AA 30-235

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM3B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: ELIPDAPLSS AAYSIRSIGE RPVLKAPVPK RQKCDHWTPC PSDTYAYRLL SGGGRSKYAK ICFEDNLLMG EQLGNVARGI NIAIVNYVTG NVTATRCFDM YEGDNSGPMT KFIQSAAPKS LLFMVTYDDG STRLNNDAKN AIEALGSKEI RNMKFRSSWV FIAAKGLELP SEIQREKINH SDAKNNRYSG WPAEIQIEGC IPKERS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human FAM3B (NP_478066.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC,1:100 - 1:200,IF,1:100 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FAM3B

Target: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Andere Bezeichnung: FAM3B (FAM3B Produkte)

Synonyme: 2-21 antikoerper, C21orf11 antikoerper, C21orf76 antikoerper, ORF9 antikoerper, PANDER antikoerper, 9030624C24Rik antikoerper, D16Jhu19e antikoerper, Pander antikoerper, RGD1311662 antikoerper, family with sequence similarity 3 member B antikoerper, family with sequence similarity 3, member B antikoerper, FAM3B antikoerper, Fam3b antikoerper

Substanzklasse: Viral Protein

Hintergrund: FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.,FAM3B,2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Immunology & Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway,FAM3B

Molekulargewicht: 20 kDa/25 kDa/30 kDa

Gen-ID: 54097

UniProt: P58499

Pathways: Hormone Transport