RPA2 Antikörper (AA 80-270)

Produktnummer ABIN3023166

Produktdetails anti-RPA2 Antikörper

Target: RPA2 (Replication Protein A2, 32kDa (RPA2))

Bindungsspezifität: AA 80-270

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequenz: IRHAEKAPTN IVYKIDDMTA APMDVRQWVD TDDTSSENTV VPPETYVKVA GHLRSFQNKK SLVAFKIMPL EDMNEFTTHI LEVINAHMVL SKANSQPSAG RAPISNPGMS EAGNFGGNSF MPANGLTVAQ NQVLNLIKAC PRPEGLNFQD LKNQLKHMSV SSIKQAVDFL SNEGHIYSTV DDDHFKSTDA E

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-270 of human RPA2 (NP_002937.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RPA2

Target: RPA2 (Replication Protein A2, 32kDa (RPA2))

Andere Bezeichnung: RPA2 (RPA2 Produkte)

Synonyme: REPA2 antikoerper, RPA32 antikoerper, 153194_at antikoerper, CG9273 antikoerper, Dmel\\CG9273 antikoerper, dRPA2 antikoerper, rpa antikoerper, zgc:109822 antikoerper, ik:tdsubc_2g1 antikoerper, xx:tdsubc_2g1 antikoerper, repa2 antikoerper, rpa32 antikoerper, RPA2 antikoerper, GB13976 antikoerper, LOC100230445 antikoerper, AA409079 antikoerper, AI325195 antikoerper, AU020965 antikoerper, RPA34 antikoerper, Rf-A2 antikoerper, replication protein A2 antikoerper, Replication protein A2 antikoerper, replication protein A2, 32kDa antikoerper, replication protein A 32 kDa subunit antikoerper, RPA2 antikoerper, Rpa2 antikoerper, rpa2 antikoerper, LOC725418 antikoerper, RPA2_2 antikoerper

Hintergrund: As part of the heterotrimeric replication protein A complex (RPA/RP-A, binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.,REPA2,RP-A p32,RP-A p34,RPA32,RPA2,RP-Ap32,RP-Ap34,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RPA2

Molekulargewicht: 29 kDa/30 kDa/38 kDa

Gen-ID: 6118

UniProt: P15927

Pathways: Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA