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CLIP Antikörper

CLIP Reaktivität: Human FACS, IF, WB Wirt: Maus Monoclonal CLIP-1133 unconjugated
Produktnummer ABIN3026079
  • Target Alle CLIP Produkte
    CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
    Reaktivität
    • 11
    • 4
    • 2
    Human
    Wirt
    • 7
    • 6
    Maus
    Klonalität
    • 8
    • 5
    Monoklonal
    Konjugat
    • 11
    • 1
    • 1
    Dieser CLIP Antikörper ist unkonjugiert
    Applikation
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
    Aufreinigung
    Protein G affinity chromatography
    Immunogen
    Recombinant full-length human protein was used as the immunogen for the CLIP antibody.
    Klon
    CLIP-1133
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    Optimal dilution of the CLIP antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,Western blot: 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the CLIP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
    Andere Bezeichnung
    CLIP (CLIP Produkte)
    Hintergrund
    Recognizes proteins of 33, 35 and 41  kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
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