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Calprotectin Antikörper

S100A8/A9 Reaktivität: Human FACS, IF, IHC (p) Wirt: Maus Monoclonal CPT-1028 unconjugated
Produktnummer ABIN3026090
  • Target Alle Calprotectin (S100A8/A9) Antikörper anzeigen
    Calprotectin (S100A8/A9)
    Reaktivität
    • 25
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 19
    • 7
    Maus
    Klonalität
    • 19
    • 7
    Monoklonal
    Konjugat
    • 11
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Dieser Calprotectin Antikörper ist unkonjugiert
    Applikation
    • 17
    • 12
    • 11
    • 10
    • 6
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    PEG precipitation
    Immunogen
    Recombinant human protein was used as the immunogen for the Calprotectin antibody.
    Klon
    CPT-1028
    Isotyp
    IgM kappa
    Top Product
    Discover our top product S100A8/A9 Primärantikörper
  • Applikationshinweise
    Optimal dilution of the Calprotectin antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM Citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (Formalin-fixed): 0.5-1 μg/mL for 30 min at RT (1),Not suitable for frozen tissues

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the Calprotectin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    Calprotectin (S100A8/A9)
    Andere Bezeichnung
    Calprotectin (S100A8/A9 Produkte)
    Synonyme
    60B8AG antikoerper, CAGB antikoerper, CFAG antikoerper, CGLB antikoerper, L1AG antikoerper, LIAG antikoerper, MAC387 antikoerper, MIF antikoerper, MRP14 antikoerper, NIF antikoerper, P14 antikoerper, Mrp14 antikoerper, MRP-14 antikoerper, p14 antikoerper, 60B8Ag antikoerper, AW546964 antikoerper, BEE22 antikoerper, Cagb antikoerper, GAGB antikoerper, L1Ag antikoerper, S100 calcium binding protein A9 antikoerper, S100 calcium binding protein A9 (calgranulin B) antikoerper, S100A9 antikoerper, S100a9 antikoerper
    Hintergrund
    Recognizes the L1 or Calprotectin molecule, also called S100A8/9 and MRP8/14, an intra-cytoplasmic antigen comprising of a 12  kDa alpha chain and a 14  kDa beta chain. Calprotectin comprises 60 % of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions. This mAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and is important for identifying macrophages in tissue sections.
    Pathways
    S100 Proteine
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