Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

TICAM1 Antikörper (C-Term)

TICAM1 Reaktivität: Human WB, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3029185
  • Target Alle TICAM1 Antikörper anzeigen
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Bindungsspezifität
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 25
    • 10
    • 3
    • 2
    Human
    Wirt
    • 22
    • 4
    • 3
    Kaninchen
    Klonalität
    • 25
    • 4
    Polyklonal
    Konjugat
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TICAM1 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the C-terminus of human TRIF (NNHMWNQRGSQAPEDKTQEAE) was used as the immunogen for this TRIF antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product TICAM1 Primärantikörper
  • Applikationshinweise
    The stated application concentrations are suggested starting points. Titration of the TRIF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the TRIF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Andere Bezeichnung
    TRIF (TICAM1 Produkte)
    Synonyme
    IIAE6 antikoerper, MyD88-3 antikoerper, PRVTIRB antikoerper, TICAM-1 antikoerper, TRIF antikoerper, AW046014 antikoerper, AW547018 antikoerper, trif antikoerper, toll like receptor adaptor molecule 1 antikoerper, toll-like receptor adaptor molecule 1 antikoerper, TICAM1 antikoerper, Ticam1 antikoerper, ticam1 antikoerper
    Hintergrund
    TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with < a href=../search_result.php?search_txt=TLR3>TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either < a href=../search_result.php?search_txt=nfkb>NFKB, < a href=../search_result.php?search_txt=ap1>AP1, or < a href=../search_result.php?search_txt=irf3>IRF3. TRIF activation of NFKB was found to occur predominantly through < a href=../search_result.php?search_txt=irak1>IRAK1 rather than < a href=../search_result.php?search_txt=irak2>IRAK2. siRNA blockage of the protein reduced IFNB production in response to dsRNA.
    UniProt
    Q8IUC6
    Pathways
    TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Sie sind hier:
Kundenservice