CACYBP Antikörper (Middle Region)

Produktnummer ABIN3029276

Produktdetails anti-CACYBP Antikörper

Target: CACYBP (Calcyclin Binding Protein (CACYBP))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACYBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human SIAH Interacting Protein (NTRWDYLTQVEKECKE) was used as the immunogen for this SIP antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the SIP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the SIP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu CACYBP

Target: CACYBP (Calcyclin Binding Protein (CACYBP))

Andere Bezeichnung: SIP (CACYBP Produkte)

Synonyme: zgc:76993 antikoerper, CACYBP antikoerper, sip antikoerper, gig5 antikoerper, pnas-107 antikoerper, s100a6bp antikoerper, T1P2.12 antikoerper, T1P2_12 antikoerper, GIG5 antikoerper, RP1-102G20.6 antikoerper, S100A6BP antikoerper, SIP antikoerper, calcyclin binding protein antikoerper, calcyclin binding protein, putative antikoerper, Calcyclin binding protein, putative antikoerper, SGS domain-containing protein antikoerper, calcyclin binding protein L homeolog antikoerper, cacybp antikoerper, CACYBP antikoerper, PB000926.02.0 antikoerper, PCHAS_145490 antikoerper, PVX_100855 antikoerper, PKH_145680 antikoerper, AT1G30070 antikoerper, cacybp.L antikoerper, Cacybp antikoerper

Hintergrund: CACYBP (Calcyclin-binding protein), also called SIP (SIAH Interacting Protein), is a protein that in humans is encoded by the CACYBP gene. The full-length SIP cDNA encodes a predicted 228-amino acid protein. Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, resulting in a predicted 80-amino acid protein, SIP-short (SIPS). The CACYBP gene is mapped on 1q25.1. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, demonstrating conservation of SGT1 and SIP protein function.

UniProt: Q9HB71

Pathways: Response to Growth Hormone Stimulus