Tumor Protein p73 Antikörper (AA 1-198)

Produktnummer ABIN3029401

Produktdetails anti-Tumor Protein p73 Antikörper

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Bindungsspezifität: AA 1-198

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tumor Protein p73 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (1-198) was used as the immunogen for this p73 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the p73 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the p73 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Tumor Protein p73

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Andere Bezeichnung: p73 (TP73 Produkte)

Synonyme: P73 antikoerper, Trp73 antikoerper, TP73 antikoerper, tp73 antikoerper, Tp73 antikoerper, p73 antikoerper, TAp73 antikoerper, zp73theta antikoerper, tumor protein p73 antikoerper, transformation related protein 73 antikoerper, TP73 antikoerper, Tp73 antikoerper, tp73 antikoerper, Trp73 antikoerper

Hintergrund: Tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of the protein. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate it is markedly increased by gamma-irradiation.

Gen-ID: 7161

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus