VCP Antikörper (C-Term)

Produktnummer ABIN3029567

Produktdetails anti-VCP Antikörper

Target: VCP (Valosin Containing Protein (VCP))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VCP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Valosin-containing protein (DNDIRKYEMFAQTLQQSR) was used as the immunogen for this VCP antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the VCP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the VCP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu VCP

Target: VCP (Valosin Containing Protein (VCP))

Andere Bezeichnung: VCP (VCP Produkte)

Synonyme: ALS14 antikoerper, IBMPFD antikoerper, TERA antikoerper, p97 antikoerper, CDC48 antikoerper, wu:fd16d05 antikoerper, wu:fj63d11 antikoerper, p93 antikoerper, 3110001E05 antikoerper, p97/VCP antikoerper, 22.26 antikoerper, 7.12 antikoerper, Apple antikoerper, BcDNA.GM02885 antikoerper, BcDNA:GM02885 antikoerper, CG2331 antikoerper, DmTER94 antikoerper, Dmel\CG2331 antikoerper, I antikoerper, Ter94 antikoerper, Tera antikoerper, VCP antikoerper, VCP ATPase antikoerper, VCP/p97 antikoerper, Vcp antikoerper, anon-WO2004063362.65 antikoerper, anon-WO2004063362.67 antikoerper, cdc48 antikoerper, dTERA antikoerper, dVCP antikoerper, dmTERA antikoerper, dvcp antikoerper, l(2)03775 antikoerper, l(2)46CFf antikoerper, l(2)46CFs antikoerper, l(2)46Ch antikoerper, pTER94 antikoerper, ter94 antikoerper, vcp antikoerper, FANCG antikoerper, valosin containing protein antikoerper, valosin containing protein S homeolog antikoerper, valosin-containing protein antikoerper, CG2331 gene product from transcript CG2331-RA antikoerper, zgc:136908 antikoerper, transitional endoplasmic reticulum ATPase antikoerper, VCP antikoerper, vcp.S antikoerper, vcp antikoerper, Vcp antikoerper, Bm1_56585 antikoerper, LOC100136246 antikoerper, TER94 antikoerper, zgc:136908 antikoerper, LOC101109680 antikoerper

Hintergrund: Valosin-containing protein, also called Cdc48, is an enzyme that in humans is encoded by the VCP gene. It is a member of the AAA+(ATPase associated with various activities) protein family. The gene maps to chromosome 9p13.3. It is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. It is involved in the formation of the transitional endoplasmic reticulum. This gene plays a role in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP is also involved in DNA damage response: recruited to double-strand breaks(DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites.

UniProt: P55072

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway