uPAR uPA Receptor (C-Term) Antikörper

Produktnummer ABIN3029776

Produktdetails

Target: uPAR uPA Receptor

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human uPAR (CNHPDLDVQYRS) was used as the immunogen for this uPAR antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the uPAR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the uPAR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Antigendetails

Target: uPAR uPA Receptor

Hintergrund: PLAUR (Plasminogen activator receptor, urokinase-type), also known as uPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol(GPI) anchor. It consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. The protein was originally identified as a saturable binding site for urokinase on the cell surface. The gene plays an important role in many normal as well as pathologic processes. It is localized to 19q13.31. uPAR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. It binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane, indicating it is an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a uPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

UniProt: Q03405