BAG2 Antikörper (N-Term)

Produktnummer ABIN3030137

Produktdetails anti-BAG2 Antikörper

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human BAG family molecular chaperone regulator 2 (MAQAKINAKANEGR) was used as the immunogen for this BAG2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the BAG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the BAG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu BAG2

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Andere Bezeichnung: BAG2 (BAG2 Produkte)

Synonyme: bag2 antikoerper, MGC89300 antikoerper, BAG2 antikoerper, ATBAG2 antikoerper, BCL-2-associated athanogene 2 antikoerper, MTG10.13 antikoerper, MTG10_13 antikoerper, BAG-2 antikoerper, dJ417I1.2 antikoerper, zgc:64195 antikoerper, 2610042A13Rik antikoerper, BC016230 antikoerper, BCL2 associated athanogene 2 antikoerper, BCL-2-associated athanogene 2 antikoerper, BCL2-associated athanogene 2 antikoerper, Bcl2-associated athanogene 2 antikoerper, bag2 antikoerper, BAG2 antikoerper, Bag2 antikoerper

Hintergrund: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these two types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

UniProt: O95816