Caspase 8 Antikörper (AA 458-473)
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- Target Alle Caspase 8 (CASP8) Antikörper anzeigen
- Caspase 8 (CASP8)
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Bindungsspezifität
- AA 458-473
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Caspase 8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- Antigen affinity
- Immunogen
- Amino acids 458-473 (TILTEVNYEVSNKDDK-human) were used as the immunogen for this Caspase-8 antibody. This sequence is from the small subunit.
- Isotyp
- IgG
- Top Product
- Discover our top product CASP8 Primärantikörper
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- Applikationshinweise
- The stated application concentrations are suggested starting points. Titration of the Caspase-8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Lagerung
- -20 °C
- Informationen zur Lagerung
- After reconstitution, the Caspase-8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Target
- Caspase 8 (CASP8)
- Andere Bezeichnung
- Caspase-8 (CASP8 Produkte)
- Synonyme
- casp8-A antikoerper, xCaspase-8 antikoerper, casp8 antikoerper, CASP8 antikoerper, CASP-8 antikoerper, FLICE antikoerper, MACH antikoerper, Mch5 antikoerper, ALPS2B antikoerper, CAP4 antikoerper, Casp-8 antikoerper, MCH5 antikoerper, caspase-8 antikoerper, zgc:92075 antikoerper, caspase 8 L homeolog antikoerper, death related ced-3/Nedd2-like protein antikoerper, caspase 8 antikoerper, caspase-8 antikoerper, caspase-8-like antikoerper, caspase 8, apoptosis-related cysteine peptidase antikoerper, casp8.L antikoerper, LOC661095 antikoerper, CASP8 antikoerper, LOC5563818 antikoerper, casp8 antikoerper, LOC100222284 antikoerper, Casp8 antikoerper
- Hintergrund
- The human CASP8 gene, whose product is also known as Caspase-8 and FLICE, encodes an interleukin-1beta converting enzyme (ICE)-related cysteine protease that is activated by the engagement of several different death receptors. It is immediately recruited to the Fas receptor once it oligomerizes, and its protease activity is crucial for the apoptotic response generated by the resulting death-inducing signaling complex (DISC). This gene contains at least 11 exons spanning approximately 30kb on human chromosome band 2q33-34. This region of chromosome 2 was previously reported as the location of the CASP10 gene, whose product is closely related to CASP8. Caspase-8 deficiency in humans is compatible with normal development and shows that the enzyme has a postnatal role in immune activation of naive lymphocytes.
- UniProt
- Q14790
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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