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CISH Antikörper (AA 241-258)

CISH Reaktivität: Human, Maus, Ratte WB, ICC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3030694
  • Target Alle CISH Antikörper anzeigen
    CISH (Cytokine Inducible SH2-Containing Protein (CISH))
    Bindungsspezifität
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 241-258
    Reaktivität
    • 24
    • 16
    • 14
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 24
    • 1
    Kaninchen
    Klonalität
    • 25
    Polyklonal
    Konjugat
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CISH Antikörper ist unkonjugiert
    Applikation
    • 15
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Antigen affinity
    Immunogen
    Amino acids 241-258 (LPLPRRMADYLRQYPFQL) were used as the immunogen for this CISH antibody (100% homologous in human, mouse and rat).
    Isotyp
    IgG
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    Discover our top product CISH Primärantikörper
  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the CISH antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the CISH antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    CISH (Cytokine Inducible SH2-Containing Protein (CISH))
    Andere Bezeichnung
    CISH (CISH Produkte)
    Synonyme
    CISH antikoerper, cis antikoerper, cish.a antikoerper, ptk9l antikoerper, twf1l antikoerper, wu:fk57g04 antikoerper, zgc:154062 antikoerper, zgc:91817 antikoerper, g18 antikoerper, socs antikoerper, cis-1 antikoerper, cish antikoerper, BACTS2 antikoerper, CIS antikoerper, CIS-1 antikoerper, G18 antikoerper, SOCS antikoerper, AI385595 antikoerper, CIS1 antikoerper, Cis antikoerper, F17 antikoerper, F23 antikoerper, cytokine inducible SH2 containing protein antikoerper, cytokine inducible SH2-containing protein antikoerper, CISH antikoerper, cish antikoerper, Cish antikoerper
    Hintergrund
    Cytokine inducible SH2-containing protein, also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CISH expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CISH. Gain- and loss-of-function studies showed that CISH accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
    UniProt
    Q9NSE2
    Pathways
    JAK-STAT Signalweg, Response to Growth Hormone Stimulus
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