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FGF8 Antikörper (C-Term)

FGF8 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3030939
  • Target Alle FGF8 Antikörper anzeigen
    FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))
    Bindungsspezifität
    • 15
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 40
    • 34
    • 27
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 52
    • 5
    • 1
    Kaninchen
    Klonalität
    • 53
    • 5
    Polyklonal
    Konjugat
    • 27
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FGF8 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 23
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the C-terminus of human FGF8 (FMKRLPRGHHTTEQSLRFEFLNY) was used as the immunogen for this FGF8 antibody (100% homologous in human, mouse and rat).
    Isotyp
    IgG
    Top Product
    Discover our top product FGF8 Primärantikörper
  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the FGF8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the FGF8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))
    Andere Bezeichnung
    FGF8 (FGF8 Produkte)
    Hintergrund
    Fibroblast growth factor 8(androgen-induced), also known as FGF8 or AIGF, is a human gene which maps to 10q24. The protein encoded by this gene are secreted proteins that interact with FGF tyrosine kinase receptors to mediate growth and development. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The temporal and spatial patterns of this gene expression suggest that FGF8 is involved in gastrulation, regionalization of the brain, and organogenesis of the limb and face as an embryonic epithelial factor. The adult expression of FGF8 is restricted to gonads, including testes and ovaries. FGF8 stimulated growth of human prostate carcinoma cells and mouse fibroblasts and mammary carcinoma cells in a dose-dependent manner. It also may play an important role in growth and patterning of limbs, face, and central nervous system. FGF8 is expressed in increased levels in breast cancer and in lactating human breast, it was also detected in human milk. A survey of other normal tissues showed that FGF8 is expressed in the proliferative cells of the skin and epithelial cells in colon, ovary, fallopian tube, and uterus.
    UniProt
    P55075
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis
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