GJB2 Antikörper (N-Term)

Produktnummer ABIN3031025

Der Kaninchen Polyklonal anti-GJB2 Antikörper wird verwendet zum Nachweis von GJB2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für GJB2 Antikörper (N-Term) (ABIN3031025)

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GJB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GJB2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GJB2 Antibody

Sequenz: MDWGTLQTIL GGVNKH

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human GJB2 (MDWGTLQTILGGVNKH) was used as the immunogen for this GJB2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the GJB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GJB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Andere Bezeichnung: GJB2

Hintergrund: Connexin 26 (CX26), also known as GAP junction protein beta2 (GJB2). Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5 % identity with rat Cx26. connexin 26(GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization