HSPG2 Antikörper (AA 524-701)

Produktnummer ABIN3031179

Produktdetails anti-HSPG2 Antikörper

Target: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Bindungsspezifität: AA 524-701

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 524-701) was used as the immunogen for this Perlecan antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Perlecan antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Perlecan antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu HSPG2

Target: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Andere Bezeichnung: Perlecan (HSPG2 Produkte)

Synonyme: HSPG antikoerper, PLC antikoerper, PRCAN antikoerper, SJA antikoerper, SJS antikoerper, SJS1 antikoerper, HSPG2 antikoerper, AI852380 antikoerper, Pcn antikoerper, Plc antikoerper, per antikoerper, Per antikoerper, heparan sulfate proteoglycan 2 antikoerper, perlecan (heparan sulfate proteoglycan 2) antikoerper, HSPG2 antikoerper, hspg2 antikoerper, Hspg2 antikoerper

Hintergrund: Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. It is a key component of the vascular extracellular matrix where it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

Gen-ID: 3339

Pathways: Glycosaminoglycan Metabolic Process, Lipid Metabolism