Hepsin Antikörper (C-Term)

Produktnummer ABIN3031191

Produktdetails anti-Hepsin Antikörper

Target: Hepsin (HPN)

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hepsin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Hepsin (KVSDFREWIFQAIKTHSEA) was used as the immunogen for this Hepsin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Hepsin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Hepsin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Hepsin

Target: Hepsin (HPN)

Andere Bezeichnung: Hepsin (HPN Produkte)

Synonyme: TMPRSS1 antikoerper, Hlb320 antikoerper, hepsin antikoerper, si:dkey-33i11.3 antikoerper, HPN antikoerper, si:dkey-33i11.3 antikoerper, Hpn antikoerper

Hintergrund: Hepsin, also known as TMPRSS1, is an enzyme that in humans is encoded by the HPN gene. Tsuji et al.(1991) mapped the gene to 19q11-q13.2. Using cDNA microarrays, Dhanasekaran et al.(2001) examined gene expression profiles of more than 50 normal and neoplastic prostate specimens and 3 common prostate cancer cell lines. Signature expression profiles of normal adjacent prostate, benign prostatic hypertrophy, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. In 3 different human cell lines, Guipponi et al.(2008) found that Hepsin was stably anchored in the endoplasmic reticulum.

UniProt: P05981

Pathways: Regulation of Hormone Metabolic Process, Sensory Perception of Sound