Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MBD4 Antikörper (C-Term)

MBD4 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3031772
  • Target Alle MBD4 Antikörper anzeigen
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Bindungsspezifität
    • 9
    • 8
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 32
    • 4
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 31
    • 1
    • 1
    Kaninchen
    Klonalität
    • 32
    • 1
    Polyklonal
    Konjugat
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    Dieser MBD4 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the C-terminus of human Methyl-CpG-Binding Domain Protein 4 (YHDWLWENHEKLSLS) was used as the immunogen for this MBD4 antibody (100% homologous in human, mouse and rat).
    Isotyp
    IgG
    Top Product
    Discover our top product MBD4 Primärantikörper
  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the MBD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the MBD4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Andere Bezeichnung
    MBD4 (MBD4 Produkte)
    Synonyme
    MED1 antikoerper, Med1 antikoerper, methyl-CpG binding domain 4, DNA glycosylase antikoerper, methyl-CpG binding domain protein 4 antikoerper, methyl-CpG binding domain 4 DNA glycosylase antikoerper, MBD4 antikoerper, Mbd4 antikoerper
    Hintergrund
    Methyl-CpG-Binding Domain Protein 4, also known as MED1, is a protein that in humans is encoded by the MBD4 gene. MBD4 specifically binds methylated DNA, colocalizes with methylated sequences, and is likely to mediate the effects of DNA methylation in mammalian cells(Hendrich and Bird, 1998). Riccio et al.(1999) mapped the gene to chromosome 3q21-q22 by FISH. Hendrich and Bird(1998) found that both MBD2 and -4 specifically bound methylated DNA in vitro and colocalized with methylated sequences in vivo. They concluded that MBD2 and -4 are likely to be mediators of the effects of DNA methylation in mammalian cells. Hendrich et al.(1999) showed that MBD4 contains a methyl-CpG-binding domain that can efficiently remove thymine or uracil from mismatched CpG sites in vitro. Furthermore, the methyl-CpG-binding domain of MBD4 binds preferentially to 5-methylcytosine CpG-TpG mismatches--the primary product of deamination at methyl-CpG.
    UniProt
    O95243
    Pathways
    DNA Reparatur
Sie sind hier:
Kundenservice