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Nicastrin Antikörper (N-Term)

NCSTN Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3031996
  • Target Alle Nicastrin (NCSTN) Antikörper anzeigen
    Nicastrin (NCSTN)
    Bindungsspezifität
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 36
    • 32
    • 21
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 49
    • 3
    Kaninchen
    Klonalität
    • 42
    • 10
    Polyklonal
    Konjugat
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nicastrin Antikörper ist unkonjugiert
    Applikation
    • 38
    • 13
    • 13
    • 9
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the N-terminus of human NCSTN (VIHVVEKEEDLQWVLTD) was used as the immunogen for this Nicastrin antibody.
    Isotyp
    IgG
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  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the Nicastrin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the Nicastrin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    Nicastrin (NCSTN)
    Andere Bezeichnung
    Nicastrin (NCSTN Produkte)
    Synonyme
    CG7012 antikoerper, Dmel\\CG7012 antikoerper, Nct antikoerper, Nic antikoerper, S5A antikoerper, ST96B antikoerper, agro antikoerper, dNct antikoerper, nic antikoerper, NCSTN antikoerper, DKFZp469O2418 antikoerper, APH2 antikoerper, 9430068N19Rik antikoerper, AA727311 antikoerper, Aph2 antikoerper, D1Dau13e antikoerper, Kiaa0253 antikoerper, mKIAA0253 antikoerper, nicastrin antikoerper, Nicastrin antikoerper, NCSTN antikoerper, nct antikoerper, ncstn antikoerper, CpipJ_CPIJ001617 antikoerper, Ncstn antikoerper, aph-2 antikoerper
    Hintergrund
    Nicastrin, also known as NCSTN, is aproteinthat is a part of the gamma secretase protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretaseprotein complex, all of which undergo significant post-translational modification before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.
    UniProt
    Q92542
    Pathways
    Notch Signalweg, Neurotrophin Signalübertragung
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