FOXO3 Antikörper (AA 471-673)

Produktnummer ABIN3042404

Produktdetails anti-FOXO3 Antikörper

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Bindungsspezifität: AA 471-673

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Forkhead box protein O3(FOXO3) detection. Tested with WB, IHC-P in Human,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Forkhead box protein O3(FOXO3) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: forkhead box O3
Protein Name: Forkhead box protein O3

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXO3A recombinant protein (Position: Q471-G673). Human FOXO3A shares 97% amino acid (aa) sequence identity with mouse FOXO3A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Andere Bezeichnung: FOXO3 (FOXO3 Produkte)

Hintergrund: Forkhead box O3, also known as FKHRL1 or FOXO3a, is a human protein encoded by the FOXO3 gene. FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3 regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3 is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.

Synonyms: AF6q21 antibody|AF6q21 protein antibody|DKFZp781A0677 antibody|FKHR2 antibody|FKHRL 1 antibody|FKHRL1 antibody|FKHRL1P2 antibody|Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 antibody|Forkhead box O3 antibody|Forkhead box O3A antibody|Forkhead box protein O3 antibody|Forkhead box protein O3A antibody|Forkhead Drosophila homolog of in rhabdomyosarcoma like 1 antibody|Forkhead homolog (rhabdomyosarcoma) like 1 antibody|Forkhead in rhabdomyosarcoma like 1 antibody|Forkhead in rhabdomyosarcoma-like 1 antibody|FOX O3A antibody|FOXO2 antibody|foxo3 antibody|FOXO3_HUMAN antibody|FOXO3A antibody|MGC12739 antibody|MGC31925 antibody

Gen-ID: 2309

UniProt: O43524

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis